The ENKORE cluster invites researchers, regulatory experts, and students to join the upcoming workshop “Advancing Adverse Outcome Pathways (AOP) Frameworks for Endocrine Disruption Research.”
This workshop is the first in a series of four thematic ENKORE workshops designed to strengthen scientific collaboration and knowledge exchange across the cluster’s partner institutions.
Participants can choose between sessions tailored to different experience levels—from beginners to advanced AOP users and developers. Each session will be guided by leading experts from ENKORE partners, the Society for the Advancement of Adverse Outcome Pathways (SAAOP), the Joint research center (JRC) of the European Commission, and the OECD – OCDE.
The full programme runs for a total of 5 hours, but participants may register only for the sessions most relevant to their expertise and interests.
Block your calendar to explore innovative ways of applying AOP frameworks in endocrine disruption research and contribute to advancing the scientific understanding of chemical safety in Europe.
Agenda
11:00-Welcome and brief intro about the online workshop
Moderator: Chiara Baudracco / Dorota Komar (Eurecat, coordinator of ENKORE AOP WG)
Session 1: Basics about the AOP framework
Moderator: You Song
11:05-11:50: Fundamentals of the AOP Framework
Speaker: Daniel Villeuenve, USEPA, SAAOP (former president), co-founder of the AOP framework
11:50-12:10: The OECD AOP coaching program
Speaker: Shihori Tanabe, National Institute of Health Sciences Japan, OECD AOP coach lead
12:10–12:30: Q&A + Break
Session 2: (q)AOP development strategies
Moderator: Anna Beroninus
12:30-12:45: Exploring AI for mechanistically informed chemical assessment
Speaker: Siegfried Morath (JRC)
12:45-13:00: Mechanistically enhancing omics data interpretation in the AOP context
Speaker: Alexandra Schaffert (Tampere University)
13:00-13:15: AOPs and NAMs-it’s a match!
Speaker: Clemens Wittwehr (JRC, SAAOP)
13:15-13:30: Making AOPs Predictive: A Brief Guide to Quantitative AOPs
Speaker: You Song (NIVA, SAAOP (councellor), OECD AOP coach, ENKORE AOP WG co-chair)
13:30-14:30: Q&A + Lunch Break
Session 3: Success stories of the AOP framework: from development to regulatory application
Moderator: Eva Serrano Candelas
14:30-14:45: AOP for skin sensitisation: an AOP Success Story
Speaker: Nathalie Delrue (OECD)
14:45-15:00: EFSA PAN project and development of human ED AOP network
Speaker: Terje Svingen & Anna Beronius (DTU & KI, PARC)
15:00-15:15: An AOP-based IATA for thyroid hormone system disruption in fish
Speaker: Dries Knapen (University of Antwerp, SAAOP president, lead of PARC AOP/IATA work)
15:15-15:25: Q&A
Session 4: Flash introduction on AOP-related work in ENKORE
Moderator: Terje Svingen
15:25: MERLON
Speaker: Terje Svingen (DTU, co-chair of ENKORE AOP WG)
15:28: EDC-MASLD
Speaker: You Song (NIVA)
15:31: HYPIEND
Speaker: Rita Ortega (ProtoQSAR)
15:34: ENDOMIX
Speaker: Raymond Pieters (Utrecht University)
15:37: NEMESIS
Speaker: Nicoletta DAlessandro (Tampere University)
